TY - JOUR
T1 - A novel molecularly imprinted electrochemical biosensor based on Ni3(HITP)2-MOF and a novel anti-fouling material for the direct detection of glucose in whole blood
AU - Zhu, Ziyu
AU - Lv, Tianjian
AU - Wang, Yuwei
AU - Nan, Shan
AU - Haotian, Ruilin
AU - Yang, Qian
AU - Liang, Axin
AU - Luo, Aiqin
N1 - Publisher Copyright:
© 2025 Elsevier B.V.
PY - 2025/10/15
Y1 - 2025/10/15
N2 - Blood glucose monitoring is crucial for the early diagnosis and treatment of diabetes; however, traditional electrochemical biosensors face challenges in detecting glucose in whole blood. To address this, we developed a fouling-resistant molecularly imprinted electrochemical biosensor. The sensor utilizes a nickel-based metal-organic framework (MOF), Ni3(HITP)2 (HITP = 2,3,6,7,10,11-hexaiminotriphenylene), as the modifier, o-phenylenediamine (o-PD) as the monomer, and glucose as the template to prepare the molecularly imprinted polymer (MIP). A phase-transition bovine serum albumin (PTB) anti-fouling layer was added to the electrode, resulting in the construction of the PTB/MIP/Ni3(HITP)2-MOF/SPCE sensor. This sensor demonstrates excellent antifouling capability, selectivity, and sensitivity, with a detection range of 1 μM to 100 mM and a limit of detection (LOD) of 0.31 μM. It requires no pre-treatment and can directly detect glucose in whole blood, offering a simple and direct method for clinical monitoring.
AB - Blood glucose monitoring is crucial for the early diagnosis and treatment of diabetes; however, traditional electrochemical biosensors face challenges in detecting glucose in whole blood. To address this, we developed a fouling-resistant molecularly imprinted electrochemical biosensor. The sensor utilizes a nickel-based metal-organic framework (MOF), Ni3(HITP)2 (HITP = 2,3,6,7,10,11-hexaiminotriphenylene), as the modifier, o-phenylenediamine (o-PD) as the monomer, and glucose as the template to prepare the molecularly imprinted polymer (MIP). A phase-transition bovine serum albumin (PTB) anti-fouling layer was added to the electrode, resulting in the construction of the PTB/MIP/Ni3(HITP)2-MOF/SPCE sensor. This sensor demonstrates excellent antifouling capability, selectivity, and sensitivity, with a detection range of 1 μM to 100 mM and a limit of detection (LOD) of 0.31 μM. It requires no pre-treatment and can directly detect glucose in whole blood, offering a simple and direct method for clinical monitoring.
KW - Anti-fouling material
KW - Electrochemical sensors
KW - Glucose
KW - Molecularly imprinted polymers
KW - Ni(HITP)-MOF
UR - http://www.scopus.com/pages/publications/105005590456
U2 - 10.1016/j.snb.2025.138028
DO - 10.1016/j.snb.2025.138028
M3 - Article
AN - SCOPUS:105005590456
SN - 0925-4005
VL - 441
JO - Sensors and Actuators, B: Chemical
JF - Sensors and Actuators, B: Chemical
M1 - 138028
ER -
