Disrupted coordination between primary and high-order cognitive networks in Parkinson’s disease based on morphological and functional analysis

Patients with Parkinson’s disease (PD) exhibit structural and functional alterations in both primary and high-order cognitive networks, but the interactions within aberrant functional networks and relevant structural foundation remains unexplored. In this study, the functional networks (FN) and the morphometric similarity networks (MSN) were constructed respectively based on the time-series data and gray matter volume from the MRI data of PD patients and controls. The efficiency, average controllability and k-shell values of the FN and MSN were calculated to evaluate their ability of information transmission and identify structural and functional abnormalities in PD. The abnormal regions were categorized into five types: regions with MSN abnormalities, regions with FN abnormalities, regions with both MSN and FN abnormalities, regions with abnormalities only in MSN but not in FN and regions with abnormalities only in FN but not in MSN. Further, the dynamic causal model (DCM) was used to evaluate the causal relationship of information flow between the identified regions. In the network property analysis of the FN, PD patients showed decreased global efficiency and connectivity in the visual network (VIS) and increased global efficiency in higher-order cognitive networks, including the ventral attention network (VAN), default mode network (DMN), and the limbic network (LIM) but no difference in MSN. In the DCM analysis of the regions, PD patients exhibited increased excitatory transition from the visual areas to the superior frontal gyrus, whereas had disturbed information flow from the visual areas to the insula and the orbitofrontal cortex. These findings suggest changes in structural and functional brain of PD patients, and advance our understanding of PD pathogenesis from different neural dimensions.